I started to use Duplicati 2 for about a month now to try it out, and it was working flawlessly for me, except for occasional time-out of the web UI. I only backup local directories, and the destinations I tried out include an external drive over USB, Google Drive, and an SSH connection.

I'm using it to backup a Firefox profile while I'm using Firefox. It backed up active files as they are being written too! I'm also using it to backup a Veracrypt container file (single 24GB file), and incremental backups worked quite well too.

Thanks for the words of advice, I will keep testing longer before I make the switch.