This region in general is a clusterfuck. If companies by now do not have a disaster recovery and resiliency strategy in place, you are just shooting yourself in the foot.
In today's world of stitching together dozens of services, who each probably do the same thing, how is one to avoid a dependency on us-east-1? Add yet another bullet to the vendor questionnaire (ugh) about whether they are singly-homed / have a failover plan?
It's turtles all the way down, and underneath all the turtles is us-east-1.